SLIME supports a wide range of operating systems and Lisp implementations. SLIME runs on Unix systems, Mac OSX, and Microsoft Windows. GNU Emacs versions 21, 22, and 23 and XEmacs version 21 are supported.
The supported Lisp implementations, roughly ordered from the best-supported, are:
Most features work uniformly across implementations, but some are prone to variation. These include the precision of placing compiler-note annotations, XREF support, and fancy debugger commands (like “restart frame”).